EFTUD2

Across TCGA cell cohorts, EFTUD2 mutation is significantly associated with the RNA expression of many other genes, with 636 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EFTUD2-associated genes across cancer lineages are ACER1, F9, and OR4D1. Each is linked with EFTUD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFTUD2-to-partner and partner-to-EFTUD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by EFTUD2-low versus EFTUD2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFTUD2→partner) and Y-score (partner→EFTUD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.095	+3.131	<.001	<.001	3	2
BLOOD_Lymphoma	F9 →	+0.017	+3.523	.006	.009	3	1
BLOOD_Lymphoma	OR4D1 →	+0.038	+3.954	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-12 →	+0.058	+4.169	<.001	.002	3	1
BLOOD_Lymphoma	KRTAP9-2 →	+0.026	+4.662	<.001	.003	3	1
LUNG_SCLC	C8orf74 →	+0.102	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 636 associations by consensus.

ACER1 by EFTUD2 expression — LARGE_INTESTINE

Explore this box plot interactively →