EFR3B

Across TCGA patient cohorts, EFR3B mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFR3B-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and Gab2. Each is linked with EFR3B in more than 1 cancer types. Because this analysis shows association rather than direction, both EFR3B-to-partner and partner-to-EFR3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by EFR3B-low versus EFR3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFR3B→partner) and Y-score (partner→EFR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.168	-3.880	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.216	-2.502	<.001	.002	3	1
UCEC	Gab2 →	+0.461	+2.584	<.001	.010	3	1
UCEC	GAPDH →	+0.500	+3.321	.017	.009	3	1
UCEC	GATA6 →	-0.180	-2.314	.004	.006	3	1
UCEC	Heregulin →	-0.152	-2.115	.001	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

14-3-3_beta by EFR3B expression — UCEC

Explore this box plot interactively →