EFR3A

Across TCGA patient cohorts, EFR3A mutation is significantly associated with the RNA expression of many other genes, with 4,364 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFR3A-associated genes across cancer lineages are COX15, ZBTB8A, and NDUFS4. Each is linked with EFR3A in more than 2 cancer types. Because this analysis shows association rather than direction, both EFR3A-to-partner and partner-to-EFR3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX15 grouped by EFR3A-low versus EFR3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFR3A→partner) and Y-score (partner→EFR3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX15 →	+0.358	+2.271	<.001	<.001	3	3
UCEC	ZBTB8A →	+0.278	+1.627	.003	.009	3	3
UCEC	NDUFS4 →	+0.368	+1.700	.002	.001	3	3
UCEC	CTDNEP1 →	+0.297	+1.949	<.001	<.001	3	3
UCEC	TCP11L1 →	+0.299	+1.960	.001	<.001	3	3
UCEC	C18orf32 →	+0.363	+1.572	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,364 associations by consensus.

COX15 by EFR3A expression — UCEC

Explore this box plot interactively →