EFR3A

Across TCGA patient cohorts, EFR3A mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFR3A-associated genes across cancer lineages are eIF4E, ACC_pS79, and GAPDH. Each is linked with EFR3A in more than 1 cancer types. Because this analysis shows association rather than direction, both EFR3A-to-partner and partner-to-EFR3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by EFR3A-low versus EFR3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFR3A→partner) and Y-score (partner→EFR3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.142	+1.807	.024	<.001	3	2
UCEC	ACC_pS79 →	+0.297	+1.999	.004	.008	3	2
UCEC	GAPDH →	+0.355	+1.584	.026	.032	3	2
UCEC	INPP4B →	-0.197	-1.415	.040	.040	3	2
UCEC	PRAS40_pT246 →	+0.127	+1.415	.012	.043	3	2
COAD	ASNS →	+0.650	+2.815	.002	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

eIF4E by EFR3A expression — UCEC

Explore this box plot interactively →