EFR3A

Across TCGA cell cohorts, EFR3A mutation is significantly associated with the RNA expression of many other genes, with 385 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EFR3A-associated genes across cancer lineages are PRSS56, TXNDC8, and MTRNR2L6. Each is linked with EFR3A in more than 1 cancer types. Because this analysis shows association rather than direction, both EFR3A-to-partner and partner-to-EFR3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS56 grouped by EFR3A-low versus EFR3A-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFR3A→partner) and Y-score (partner→EFR3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PRSS56 →	+0.417	+3.807	.003	.003	3	1
STOMACH	TXNDC8 →	+0.027	+4.285	<.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.130	+4.357	<.001	.006	3	1
LARGE_INTESTINE	PES1 →	+0.448	+3.023	.005	<.001	3	1
LARGE_INTESTINE	GCAT →	+1.291	+2.158	<.001	.004	3	1
LARGE_INTESTINE	ANKRD54 →	+0.477	+2.244	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 385 associations by consensus.

PRSS56 by EFR3A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →