EFNB3

Across TCGA patient cohorts, EFNB3 mutation is significantly associated with the RNA expression of many other genes, with 1,625 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFNB3-associated genes across cancer lineages are NTAN1, PPP2R2D, and RIMKLA. Each is linked with EFNB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFNB3-to-partner and partner-to-EFNB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NTAN1 grouped by EFNB3-low versus EFNB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFNB3→partner) and Y-score (partner→EFNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NTAN1 →	+0.512	+3.616	<.001	.001	3	2
UCEC	PPP2R2D →	+0.275	+2.740	.006	.003	3	2
UCEC	RIMKLA →	+0.678	+2.695	.003	<.001	3	2
HNSC	OR1L1 →	+0.035	+5.008	<.001	.004	3	2
UCEC	RPL23AP82 →	+0.433	+2.673	<.001	<.001	3	2
UCEC	SDHB →	+0.369	+2.455	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,625 associations by consensus.

NTAN1 by EFNB3 expression — UCEC

Explore this box plot interactively →