EFNB3

Across TCGA patient cohorts, EFNB3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFNB3-associated genes across cancer lineages are GAPDH, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with EFNB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFNB3-to-partner and partner-to-EFNB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by EFNB3-low versus EFNB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFNB3→partner) and Y-score (partner→EFNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.635	+2.584	.004	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.852	+2.827	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.095	-2.973	.021	.035	3	1
UCEC	eEF2 →	+0.401	+2.459	.006	.019	3	1
UCEC	ERK2 →	+0.296	+3.700	<.001	.001	3	1
UCEC	GATA6 →	-0.157	-2.985	.016	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

GAPDH by EFNB3 expression — UCEC

Explore this box plot interactively →