EFNB3

Across TCGA cell cohorts, EFNB3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EFNB3-associated genes across cancer lineages are CRX, TTLL8, and MDGA2. Each is linked with EFNB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFNB3-to-partner and partner-to-EFNB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRX grouped by EFNB3-low versus EFNB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFNB3→partner) and Y-score (partner→EFNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CRX →	+0.016	+3.347	.008	.005	3	1
LARGE_INTESTINE	TTLL8 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	MDGA2 →	+0.152	+3.554	<.001	.007	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR10H5 →	+0.013	+3.347	.008	.005	3	1
LARGE_INTESTINE	OR52H1 →	+0.032	+3.347	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CRX by EFNB3 expression — LARGE_INTESTINE

Explore this box plot interactively →