EFNB2

Across TCGA patient cohorts, EFNB2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFNB2-associated genes across cancer lineages are ASNS, eIF4E, and eIF4G. Each is linked with EFNB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFNB2-to-partner and partner-to-EFNB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by EFNB2-low versus EFNB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFNB2→partner) and Y-score (partner→EFNB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.461	+2.700	<.001	.005	3	2
UCEC	eIF4E →	+0.212	+2.247	.006	.001	3	1
UCEC	eIF4G →	+0.260	+2.459	.022	.018	3	1
UCEC	A-Raf_pS299 →	-0.124	-1.847	.004	.008	3	1
UCEC	FASN →	+0.327	+1.700	.023	.042	3	1
UCEC	ACC_pS79 →	+0.392	+2.247	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ASNS by EFNB2 expression — UCEC

Explore this box plot interactively →