EFNB1

Across TCGA patient cohorts, EFNB1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFNB1-associated genes across cancer lineages are PCNA, TFRC, and ATM. Each is linked with EFNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFNB1-to-partner and partner-to-EFNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by EFNB1-low versus EFNB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFNB1→partner) and Y-score (partner→EFNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.272	+2.415	.001	.003	3	2
UCEC	TFRC →	+0.561	+3.169	.008	.018	3	2
UCEC	ATM →	-0.547	-2.571	.002	.010	3	2
UCEC	EGFR_pY1068 →	-0.328	-2.415	.001	.003	3	1
UCEC	eIF4E →	+0.253	+3.087	.002	<.001	2	2
UCEC	A-Raf_pS299 →	-0.214	-3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

PCNA by EFNB1 expression — UCEC

Explore this box plot interactively →