EFNA4

Across TCGA patient cohorts, EFNA4 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFNA4-associated genes across cancer lineages are 14-3-3_beta, Heregulin, and Akt_pS473. Each is linked with EFNA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFNA4-to-partner and partner-to-EFNA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by EFNA4-low versus EFNA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFNA4→partner) and Y-score (partner→EFNA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.197	-3.295	<.001	.009	3	1
UCEC	Heregulin →	-0.206	-2.986	.001	.035	3	1
UCEC	Akt_pS473 →	+1.056	+2.999	.004	.035	3	1
UCEC	Akt_pT308 →	+0.805	+2.999	.014	.035	3	1
UCEC	p90 RSK →	+0.219	+2.183	.028	.035	3	1
UCEC	PRAS40_pT246 →	+0.287	+2.183	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

14-3-3_beta by EFNA4 expression — UCEC

Explore this box plot interactively →