EFNA4

Across TCGA cell cohorts, EFNA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,549 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EFNA4-associated GO terms across cancer lineages are Response to staurosporine, Cellular response to staurosporine, and Cytotoxic T cell degranulation. Each is linked with EFNA4 in more than 9 cancer types. Because this analysis shows association rather than direction, both EFNA4-to-partner and partner-to-EFNA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to staurosporine grouped by EFNA4-low versus EFNA4-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EFNA4→partner) and Y-score (partner→EFNA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Response to staurosporine →	+0.160	+1.512	.001	<.001	3	10
LUNG_SCLC	Cellular response to staurosporine →	+0.160	+1.512	.001	<.001	3	10
BREAST	Cytotoxic T cell degranulation →	+0.222	+1.452	.003	<.001	3	9
BLOOD_Leukemia	Cardiac muscle cell-cardiac muscle cell adhesion →	+0.655	+0.729	<.001	<.001	3	9
BLOOD_Leukemia	Bundle of His cell-Purkinje myocyte adhesion involved in cell communication →	+0.678	+0.765	<.001	<.001	3	9
STOMACH	Ephrin receptor signaling pathway →	+0.172	+1.190	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,549 associations by consensus.

Response to staurosporine by EFNA4 expression — LUNG_SCLC

Explore this box plot interactively →