EFNA1

Across TCGA pan-cancer cohorts, EFNA1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated EFNA1 data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher EFNA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EFNA1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

CCRCC, LSCC, and OV are the cancer types where EFNA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.698	0.918	.001	20	view →
LSCC	OS	Tertile	All	1.000	0.921	.033	6	view →
OV	DFS	Median	All	0.670	1.000	.030	4	view →
PDAC	OS	Median	III,IV	0.196	0.788	.010	4	view →
HNSC	OS	Median	III,IV	0.520	1.000	.040	2	view →
LUAD	OS	Median	All	0.933	0.700	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

EFNA1–CCRCC (DFS)

Open the CCRCC breakdown →