EFNA1

Across TCGA cell cohorts, EFNA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,662 significant associations in total. BONE shows the largest number of these associations.

The most reproducible EFNA1-associated GO terms across cancer lineages are Negative regulation of dendritic spine morphogenesis, Heart valve formation, and Maintenance of blood-brain barrier. Each is linked with EFNA1 in more than 11 cancer types. Because this analysis shows association rather than direction, both EFNA1-to-partner and partner-to-EFNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of dendritic spine morphogenesis grouped by EFNA1-low versus EFNA1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EFNA1→partner) and Y-score (partner→EFNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of dendritic spine morphogenesis →	+0.460	+1.701	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Heart valve formation →	+0.205	+3.037	<.001	<.001	3	11
LUNG_NSCLC_LUSC	Maintenance of blood-brain barrier →	+0.211	+2.394	.003	<.001	2	12
OVARY	T cell mediated cytotoxicity →	+0.261	+2.333	<.001	<.001	3	10
BONE	Negative regulation of dendritic spine development →	+0.133	+1.641	.008	.005	2	11
OVARY	Protein targeting to Golgi apparatus →	+0.212	+2.173	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,662 associations by consensus.

Negative regulation of dendritic spine morphogenesis by EFNA1 expression — SOFT_TISSUE

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