Across TCGA patient cohorts, EFHC2 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFHC2-associated genes across cancer lineages are Shc_pY317, eIF4E, and ERK2. Each is linked with EFHC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both EFHC2-to-partner and partner-to-EFHC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFHC2→partner) and Y-score (partner→EFHC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.127	-1.502	.006	.027	3	3
UCEC	eIF4E →	+0.165	+1.643	.011	.003	3	2
UCEC	ERK2 →	+0.157	+1.584	.008	.017	3	2
UCEC	Myosin-IIa_pS1943 →	+0.126	+1.214	.049	.018	3	2
UCEC	p21 →	+0.129	+2.087	.030	.005	3	2
UCEC	Rab25 →	-0.299	-3.807	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration

EFHC2 survival (RNA) · tumor vs normal (RNA) · all EFHC2 data types