EFHC1

Across TCGA patient cohorts, EFHC1 mutation is significantly associated with the RNA expression of many other genes, with 1,856 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFHC1-associated genes across cancer lineages are KMT5AP1, MAGEA2B, and LINC02438. Each is linked with EFHC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFHC1-to-partner and partner-to-EFHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KMT5AP1 grouped by EFHC1-low versus EFHC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFHC1→partner) and Y-score (partner→EFHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KMT5AP1 →	+0.192	+1.741	<.001	.006	3	2
LUAD	MAGEA2B →	+0.156	+4.533	<.001	<.001	3	2
LUAD	LINC02438 →	+1.394	+3.798	<.001	.005	3	2
LUAD	MIR378F →	+0.323	+6.342	<.001	<.001	3	2
LUAD	GAGE2E →	+0.167	+5.197	<.001	<.001	3	2
SKCM	ZNF77 →	+0.511	+3.195	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,856 associations by consensus.

KMT5AP1 by EFHC1 expression — UCEC

Explore this box plot interactively →