EFHC1

Across TCGA cell cohorts, EFHC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,965 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EFHC1-associated GO terms across cancer lineages are Intraciliary anterograde transport, Protein localization to cilium, and Regulation of cilium assembly. Each is linked with EFHC1 in more than 15 cancer types. Because this analysis shows association rather than direction, both EFHC1-to-partner and partner-to-EFHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intraciliary anterograde transport grouped by EFHC1-low versus EFHC1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EFHC1→partner) and Y-score (partner→EFHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Intraciliary anterograde transport →	+0.115	+1.306	<.001	<.001	3	16
LUNG_SCLC	Protein localization to cilium →	+0.053	+1.013	<.001	<.001	3	15
KIDNEY	Regulation of cilium assembly →	+0.063	+1.019	<.001	.001	3	13
LIVER	Non-motile cilium assembly →	+0.087	+1.381	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Protein localization to vacuole →	+0.097	+1.256	<.001	<.001	3	12
STOMACH	Golgi to plasma membrane transport →	+0.081	+1.184	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,965 associations by consensus.

Intraciliary anterograde transport by EFHC1 expression — LUNG_SCLC

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