EFHC1

Across TCGA cell cohorts, EFHC1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EFHC1-associated genes across cancer lineages are PRR27, GLT6D1, and OR6B1. Each is linked with EFHC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFHC1-to-partner and partner-to-EFHC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR27 grouped by EFHC1-low versus EFHC1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFHC1→partner) and Y-score (partner→EFHC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRR27 →	+0.089	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	GLT6D1 →	+0.022	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	OR6B1 →	+0.009	+4.643	<.001	.005	3	1
BLOOD_Leukemia	ADRA1A →	+0.242	+4.705	<.001	.003	3	1
BLOOD_Leukemia	DEFB134 →	+0.017	+4.969	<.001	.003	3	1
LUNG_NSCLC_LUAD	SPINT4 →	+0.051	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PRR27 by EFHC1 expression — BLOOD_Lymphoma

Explore this box plot interactively →