EFHB

Across TCGA patient cohorts, EFHB protein abundance is significantly associated with the RNA expression of many other genes, with 291 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible EFHB-associated genes across cancer lineages are AKAP14, NEDD8, and ACRV1. Each is linked with EFHB in more than 1 cancer types. Because this analysis shows association rather than direction, both EFHB-to-partner and partner-to-EFHB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EFHB versus AKAP14 in LUAD, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFHB→partner) and Y-score (partner→EFHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AKAP14 →	+0.772	+1.411	<.001	<.001	3	2
HNSC	NEDD8 →	-0.714	-1.019	.001	.008	3	1
HNSC	ACRV1 →	+1.088	+1.142	.004	.006	3	1
HNSC	KIF23 →	+1.240	+1.617	.005	.003	3	1
HNSC	PLK4 →	+1.125	+1.875	<.001	.009	3	1
HNSC	CYP4A22 →	+0.742	+1.185	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 291 associations by consensus.

EFHB vs AKAP14 — LUAD

Explore this scatter interactively →