EFHB

Across TCGA patient cohorts, EFHB mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFHB-associated genes across cancer lineages are C-Raf, INPP4B, and FASN. Each is linked with EFHB in more than 2 cancer types. Because this analysis shows association rather than direction, both EFHB-to-partner and partner-to-EFHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by EFHB-low versus EFHB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFHB→partner) and Y-score (partner→EFHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.133	+1.440	.002	.022	3	3
SKCM	INPP4B →	-0.162	-1.687	.021	.040	3	3
COAD	FASN →	+0.433	+3.008	.032	.019	3	2
COAD	TSC1 →	-0.367	-2.991	.010	.036	3	2
COAD	ASNS →	+0.894	+3.008	<.001	.019	3	2
UCEC	4E-BP1 →	+0.317	+3.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

C-Raf by EFHB expression — UCEC

Explore this box plot interactively →