EFHB

Across TCGA cell cohorts, EFHB RNA expression is significantly associated with the go_rna of many other GO terms, with 1,408 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible EFHB-associated GO terms across cancer lineages are Regulation of store-operated calcium entry, Cilium movement involved in cell motility, and Cilium or flagellum-dependent cell motility. Each is linked with EFHB in more than 10 cancer types. Because this analysis shows association rather than direction, both EFHB-to-partner and partner-to-EFHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of store-operated calcium entry grouped by EFHB-low versus EFHB-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EFHB→partner) and Y-score (partner→EFHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of store-operated calcium entry →	-0.113	-0.410	.007	.007	2	11
LUNG_SCLC	Cilium movement involved in cell motility →	-0.095	-0.680	.002	<.001	3	8
LUNG_SCLC	Cilium or flagellum-dependent cell motility →	-0.081	-0.650	.005	.001	2	8
LUNG_SCLC	Cilium-dependent cell motility →	-0.081	-0.650	.005	.001	2	8
LUNG_SCLC	Flagellated sperm motility →	-0.106	-0.609	.001	<.001	3	6
CNS	Intraciliary anterograde transport →	+0.042	+0.333	.009	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,408 associations by consensus.

Regulation of store-operated calcium entry by EFHB expression — LUNG_SCLC

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