EFHB

Across TCGA cell cohorts, EFHB mutation is significantly associated with the RNA expression of many other genes, with 114 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EFHB-associated genes across cancer lineages are PLA2G3, RGCC, and SH3GL2. Each is linked with EFHB in more than 1 cancer types. Because this analysis shows association rather than direction, both EFHB-to-partner and partner-to-EFHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G3 grouped by EFHB-low versus EFHB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFHB→partner) and Y-score (partner→EFHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLA2G3 →	+0.877	+3.082	.002	.007	3	1
LARGE_INTESTINE	RGCC →	-1.587	-3.321	.003	.003	3	1
LARGE_INTESTINE	SH3GL2 →	+0.899	+3.743	.005	<.001	3	1
LARGE_INTESTINE	SIAE →	+1.032	+3.169	.009	.009	3	1
LARGE_INTESTINE	SPCS1 →	+0.368	+2.628	.002	.002	3	1
LARGE_INTESTINE	ORC4 →	+0.519	+3.169	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

PLA2G3 by EFHB expression — LARGE_INTESTINE

Explore this box plot interactively →