EFEMP2

Across TCGA patient cohorts, EFEMP2 mutation is significantly associated with the RNA expression of many other genes, with 1,038 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFEMP2-associated genes across cancer lineages are RNA5SP131, MIR3135A, and RNA5SP346. Each is linked with EFEMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFEMP2-to-partner and partner-to-EFEMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP131 grouped by EFEMP2-low versus EFEMP2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFEMP2→partner) and Y-score (partner→EFEMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP131 →	+0.341	+5.342	<.001	.002	3	2
CESC	MIR3135A →	+0.448	+4.503	.001	.005	3	2
BRCA	RNA5SP346 →	+0.267	+7.731	<.001	.009	3	2
COAD	RNU6-633P →	+0.497	+3.789	<.001	.004	3	2
COAD	RNU6-805P →	+0.390	+3.957	.002	.003	3	2
COAD	RNU6-897P →	+0.573	+4.017	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,038 associations by consensus.

RNA5SP131 by EFEMP2 expression — CESC

Explore this box plot interactively →