EFEMP2

Across TCGA patient cohorts, EFEMP2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFEMP2-associated genes across cancer lineages are JNK_pT183_Y185, VHL, and Caspase-7-cleavedD198. Each is linked with EFEMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFEMP2-to-partner and partner-to-EFEMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by EFEMP2-low versus EFEMP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFEMP2→partner) and Y-score (partner→EFEMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.188	-1.986	.004	.010	3	2
UCEC	VHL →	-1.337	-3.169	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.529	+1.894	.023	.030	3	2
UCEC	14-3-3_beta →	-0.112	-3.564	.004	.002	3	1
UCEC	A-Raf_pS299 →	-0.117	-1.584	.012	.036	3	1
UCEC	JNK2 →	+0.173	+1.884	.026	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

JNK_pT183_Y185 by EFEMP2 expression — UCEC

Explore this box plot interactively →