EFEMP2

Across TCGA cell cohorts, EFEMP2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EFEMP2-associated genes across cancer lineages are TTLL8, GUCA1A, and CRYBB3. Each is linked with EFEMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFEMP2-to-partner and partner-to-EFEMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL8 grouped by EFEMP2-low versus EFEMP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFEMP2→partner) and Y-score (partner→EFEMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL8 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	GUCA1A →	+0.052	+3.841	<.001	.003	3	1
BLOOD_Leukemia	CRYBB3 →	+0.114	+4.152	<.001	.009	3	1
BLOOD_Leukemia	SLC35G3 →	+0.036	+4.874	.001	.002	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.092	+4.539	<.001	.007	3	1
BLOOD_Leukemia	GIMD1 →	+0.039	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

TTLL8 by EFEMP2 expression — LARGE_INTESTINE

Explore this box plot interactively →