EFEMP1

Across TCGA pan-cancer cohorts, EFEMP1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of EFEMP1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where EFEMP1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types EFEMP1 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

COAD, LUAD, and PDAC are the cancer types where EFEMP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EFEMP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.736	<.001	11	view →
LUAD	Female	II,III,IV	−0.521	<.001	9	view →
PDAC	Male	All	+1.246	<.001	8	view →
LSCC	Female	All	−0.818	<.001	8	view →
CCRCC	All	All	+0.363	.001	7	view →
HNSC	All	All	+0.188	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

EFEMP1–COAD

Open the COAD breakdown →