EFCC1

Across TCGA cell cohorts, EFCC1 mutation is significantly associated with the mutation status of many other genes, with 920 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EFCC1-associated genes across cancer lineages are UNKL, GRIK4, and PKD1L1. Each is linked with EFCC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EFCC1-to-partner and partner-to-EFCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UNKL grouped by EFCC1-low versus EFCC1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFCC1→partner) and Y-score (partner→EFCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	UNKL →	+5.339	+4.772	.004	.004	1	3
LUNG_NSCLC_LUAD	GRIK4 →	+4.339	+4.339	.009	.009	1	3
BLOOD_Leukemia	PKD1L1 →	+2.115	+3.198	.009	.009	1	3
BLOOD_Leukemia	PNPLA2 →	+3.285	+3.662	.004	.004	1	3
BLOOD_Leukemia	CDK10 →	+5.285	+4.321	.005	.005	1	3
LARGE_INTESTINE	PVRIG →	+5.087	+4.523	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 920 associations by consensus.

UNKL by EFCC1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →