Across TCGA pan-cancer cohorts, EFCAB8 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated EFCAB8 data layer compared with 22 for mass-spec protein.
The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher EFCAB8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated EFCAB8 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.
CESC, UCEC, and ESCA are the cancer types where EFCAB8 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.