EFCAB3

Across TCGA patient cohorts, EFCAB3 mutation is significantly associated with the RNA expression of many other genes, with 1,858 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFCAB3-associated genes across cancer lineages are NICN2P, MIR4727, and ARRDC3-AS1. Each is linked with EFCAB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both EFCAB3-to-partner and partner-to-EFCAB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NICN2P grouped by EFCAB3-low versus EFCAB3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFCAB3→partner) and Y-score (partner→EFCAB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	NICN2P →	+0.102	+4.883	<.001	.002	3	3
BLCA	MIR4727 →	+0.474	+4.899	.002	.005	3	2
SKCM	ARRDC3-AS1 →	+0.276	+3.369	.003	.004	3	2
CESC	RNA5SP299 →	+0.441	+5.812	<.001	.003	3	2
SKCM	NPPA-AS1 →	+0.740	+3.604	<.001	.001	3	2
SKCM	UBFD1P1 →	+0.013	+3.402	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,858 associations by consensus.

NICN2P by EFCAB3 expression — BLCA

Explore this box plot interactively →