EFCAB3

Across TCGA cell cohorts, EFCAB3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EFCAB3-associated genes across cancer lineages are CEACAM4, PRG3, and SLC35G3. Each is linked with EFCAB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFCAB3-to-partner and partner-to-EFCAB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEACAM4 grouped by EFCAB3-low versus EFCAB3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFCAB3→partner) and Y-score (partner→EFCAB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CEACAM4 →	+0.030	+5.321	.004	.005	3	1
LARGE_INTESTINE	PRG3 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	SLC35G3 →	+0.011	+4.467	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	PYDC2 →	+0.108	+4.415	<.001	.007	3	1
LARGE_INTESTINE	OR6Q1 →	+0.022	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CEACAM4 by EFCAB3 expression — CNS

Explore this box plot interactively →