EFCAB14

Across TCGA patient cohorts, EFCAB14 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFCAB14-associated genes across cancer lineages are GAPDH, PCNA, and PEA-15_pS116. Each is linked with EFCAB14 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFCAB14-to-partner and partner-to-EFCAB14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by EFCAB14-low versus EFCAB14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFCAB14→partner) and Y-score (partner→EFCAB14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.415	+3.321	.044	.009	3	2
UCEC	PCNA →	+0.233	+3.321	.004	.009	3	2
UCEC	PEA-15_pS116 →	+0.381	+1.874	.004	.049	3	2
UCEC	Cyclin-B1 →	+0.790	+3.584	<.001	.002	3	2
UCEC	Dvl3 →	+0.189	+2.321	.007	.033	3	2
UCEC	14-3-3_beta →	-0.103	-2.432	.007	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

GAPDH by EFCAB14 expression — UCEC

Explore this box plot interactively →