EFCAB14

Across TCGA cell cohorts, EFCAB14 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EFCAB14-associated genes across cancer lineages are SH3GL2, FAM124A, and MTNR1A. Each is linked with EFCAB14 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFCAB14-to-partner and partner-to-EFCAB14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by EFCAB14-low versus EFCAB14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFCAB14→partner) and Y-score (partner→EFCAB14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.686	+3.667	<.001	<.001	3	1
LARGE_INTESTINE	FAM124A →	+0.749	+3.295	<.001	.006	3	1
LARGE_INTESTINE	MTNR1A →	+0.565	+3.064	<.001	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.008	+2.977	<.001	.006	3	1
LARGE_INTESTINE	KAT5 →	+0.464	+3.302	.003	.008	3	1
LARGE_INTESTINE	FAM153B →	+0.425	+3.011	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

SH3GL2 by EFCAB14 expression — LARGE_INTESTINE

Explore this box plot interactively →