EFCAB12

Across TCGA patient cohorts, EFCAB12 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFCAB12-associated genes across cancer lineages are Caspase-7-cleavedD198, PKC-delta_pS664, and Shc_pY317. Each is linked with EFCAB12 in more than 3 cancer types. Because this analysis shows association rather than direction, both EFCAB12-to-partner and partner-to-EFCAB12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by EFCAB12-low versus EFCAB12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFCAB12→partner) and Y-score (partner→EFCAB12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.975	+1.894	<.001	.030	3	4
UCEC	PKC-delta_pS664 →	-0.100	-3.169	.038	.018	3	3
UCEC	Shc_pY317 →	-0.140	-2.000	.022	.030	3	2
UCEC	ATM →	-0.509	-3.459	.005	.005	3	2
UCEC	EGFR_pY1068 →	-0.264	-2.700	.008	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.137	-1.893	.043	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Caspase-7-cleavedD198 by EFCAB12 expression — UCEC

Explore this box plot interactively →