EFCAB1

Across TCGA pan-cancer cohorts, EFCAB1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated EFCAB1 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher EFCAB1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated EFCAB1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UVM show a favorable association.

KICH, BLCA, and BRCA are the cancer types where EFCAB1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	II,III,IV	0.543	0.960	.001	62	view →
BLCA	OS	Quartile	All	0.375	0.576	.007	49	view →
BRCA	OS	Median	III,IV	0.681	0.370	<.001	36	view →
ACC	DFS	Quartile	II,III,IV	0.300	0.734	.004	36	view →
UVM	DFS	Quartile	All	0.866	0.489	.004	26	view →
UCEC	OS	Tertile	All	0.965	0.896	.004	26	view →
LUAD	DFS	Median	IV	0.212	0.777	.001	18	view →
KIRP	DFS	Tertile	II,III,IV	1.000	0.425	.035	13	view →
STAD	DFS	Quartile	All	0.481	0.622	.028	12	view →
PAAD	OS	Quartile	All	0.530	0.705	.032	9	view →
THYM	DFS	Quartile	All	0.986	0.828	.015	7	view →
HNSC	OS	Tertile	IV	0.694	0.556	.028	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

EFCAB1–KICH (OS)

Open the KICH breakdown →