EEFSEC

Across TCGA pan-cancer cohorts, EEFSEC mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of EEFSEC’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where EEFSEC mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types EEFSEC is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, LSCC, and PDAC are the cancer types where EEFSEC tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EEFSEC mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	−0.256	<.001	10	view →
LSCC	Male	II,III,IV	+0.232	<.001	9	view →
PDAC	Female	II,III,IV	−0.745	<.001	8	view →
HNSC	Male	IV	+0.299	<.001	8	view →
LUAD	Male	All	+0.123	<.001	5	view →
COAD	Male	All	−0.093	.006	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

EEFSEC–CCRCC

Open the CCRCC breakdown →