EEF2K

Across TCGA patient cohorts, EEF2K mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EEF2K-associated genes across cancer lineages are IGFBP2, p90 RSK, and Rad50. Each is linked with EEF2K in more than 2 cancer types. Because this analysis shows association rather than direction, both EEF2K-to-partner and partner-to-EEF2K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by EEF2K-low versus EEF2K-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EEF2K→partner) and Y-score (partner→EEF2K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.689	-2.000	.002	.029	3	2
UCEC	p90 RSK →	+0.203	+2.700	.002	.005	3	2
UCEC	Rad50 →	-0.279	-2.459	<.001	<.001	3	2
UCEC	S6_pS235_S236 →	+0.398	+2.321	.008	.005	3	2
UCEC	S6_pS240_S244 →	+0.415	+2.070	.003	.001	3	2
UCEC	Cyclin-B1 →	+0.399	+1.874	.040	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

IGFBP2 by EEF2K expression — UCEC

Explore this box plot interactively →