EEF2

Across TCGA patient cohorts, EEF2 mutation is significantly associated with the RNA expression of many other genes, with 3,173 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EEF2-associated genes across cancer lineages are COQ3, C9orf40, and PSMA3. Each is linked with EEF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both EEF2-to-partner and partner-to-EEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COQ3 grouped by EEF2-low versus EEF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EEF2→partner) and Y-score (partner→EEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COQ3 →	+0.345	+1.625	.002	.002	3	4
UCEC	C9orf40 →	+0.553	+1.887	<.001	<.001	3	4
COAD	PSMA3 →	+0.508	+3.352	.001	.005	3	4
UCEC	SRP54 →	+0.369	+1.860	.001	<.001	3	3
UCEC	LEPROTL1 →	+0.322	+4.119	<.001	<.001	3	3
UCEC	DCTN6 →	+0.301	+2.145	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,173 associations by consensus.

COQ3 by EEF2 expression — UCEC

Explore this box plot interactively →