EEF2

Across TCGA patient cohorts, EEF2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EEF2-associated genes across cancer lineages are TIGAR, eIF4E, and FASN. Each is linked with EEF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EEF2-to-partner and partner-to-EEF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by EEF2-low versus EEF2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EEF2→partner) and Y-score (partner→EEF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TIGAR →	+0.155	+2.824	.041	.034	3	2
UCEC	eIF4E →	+0.123	+2.070	.039	.001	3	2
UCEC	FASN →	+0.287	+1.398	.010	.004	3	2
UCEC	ATM →	-0.308	-1.489	.016	.025	3	2
BLCA	p27_pT198 →	+0.132	+3.169	.020	.019	3	1
UCEC	14-3-3_beta →	-0.057	-1.253	.046	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

TIGAR by EEF2 expression — BLCA

Explore this box plot interactively →