Across TCGA pan-cancer cohorts, EEF1E1-BLOC1S5 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of EEF1E1-BLOC1S5’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where EEF1E1-BLOC1S5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EEF1E1-BLOC1S5 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
KIRC, KIRP, and BRCA are the cancer types where EEF1E1-BLOC1S5 tumor–normal differential expression is most reproducible.