EED

Across TCGA cell cohorts, EED mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EED-associated genes across cancer lineages are CCDC54, LINGO4, and CENPVL1. Each is linked with EED in more than 1 cancer types. Because this analysis shows association rather than direction, both EED-to-partner and partner-to-EED results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC54 grouped by EED-low versus EED-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EED→partner) and Y-score (partner→EED) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC54 →	+0.140	+3.736	<.001	.004	3	1
LARGE_INTESTINE	LINGO4 →	+0.159	+3.584	<.001	.004	3	1
LARGE_INTESTINE	CENPVL1 →	+0.127	+2.925	.001	.007	3	1
LARGE_INTESTINE	F11 →	+0.046	+3.297	<.001	.002	3	1
CNS	FSHB →	+0.032	+5.321	<.001	.005	3	1
CNS	MBD3L2 →	+2.479	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CCDC54 by EED expression — LARGE_INTESTINE

Explore this box plot interactively →