EEA1

Across TCGA pan-cancer cohorts, EEA1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EEA1 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher EEA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EEA1 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

CCRCC, COAD, and LUAD are the cancer types where EEA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.510	0.843	.001	26	view →
COAD	DFS	Quartile	All	1.000	0.876	.031	18	view →
LUAD	DFS	Tertile	All	0.667	0.407	.034	2	view →
HNSC	DFS	Quartile	IV	0.467	0.763	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

EEA1–CCRCC (DFS)

Open the CCRCC breakdown →