EEA1

Across TCGA pan-cancer cohorts, EEA1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of EEA1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where EEA1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types EEA1 is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

CCRCC, HNSC, and LSCC are the cancer types where EEA1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EEA1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.274	<.001	9	view →
HNSC	Male	IV	−0.362	<.001	8	view →
LSCC	Male	III,IV	−0.328	<.001	8	view →
LUAD	All	All	−0.099	<.001	5	view →
OV	All	All	−0.541	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

EEA1–CCRCC

Open the CCRCC breakdown →