EEA1

Across TCGA patient cohorts, EEA1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,249 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible EEA1-associated genes across cancer lineages are SRPX2, ZCCHC24, and LRRN4CL. Each is linked with EEA1 in more than 7 cancer types. Because this analysis shows association rather than direction, both EEA1-to-partner and partner-to-EEA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EEA1 versus SRPX2 in COAD, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EEA1→partner) and Y-score (partner→EEA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SRPX2 →	+1.125	+0.199	<.001	.001	3	8
BRCA	ZCCHC24 →	+1.049	+0.322	<.001	<.001	3	8
UCEC	LRRN4CL →	+1.142	+0.236	<.001	<.001	3	8
OV	DAB2 →	+0.876	+0.291	<.001	.001	3	7
BRCA	COLEC12 →	+1.290	+0.404	<.001	<.001	3	7
CCRCC	NBL1 →	+1.147	+0.351	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,249 associations by consensus.

EEA1 vs SRPX2 — COAD

Explore this scatter interactively →