EEA1

Across TCGA patient cohorts, EEA1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EEA1-associated genes across cancer lineages are Shc_pY317, ATM, and eIF4E. Each is linked with EEA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EEA1-to-partner and partner-to-EEA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by EEA1-low versus EEA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EEA1→partner) and Y-score (partner→EEA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.147	-1.440	.001	.022	3	3
UCEC	ATM →	-0.662	-1.947	<.001	<.001	3	3
UCEC	eIF4E →	+0.130	+1.947	.044	<.001	3	2
UCEC	p27 →	-0.174	-2.700	.009	.005	3	2
UCEC	PCNA →	+0.205	+2.415	.001	.002	3	2
UCEC	Rab25 →	-0.219	-1.263	.030	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Shc_pY317 by EEA1 expression — UCEC

Explore this box plot interactively →