EEA1

Across TCGA cell cohorts, EEA1 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EEA1-associated genes across cancer lineages are OR2H1, XAGE3, and SCYGR2. Each is linked with EEA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EEA1-to-partner and partner-to-EEA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2H1 grouped by EEA1-low versus EEA1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EEA1→partner) and Y-score (partner→EEA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	2
OESOPHAGUS	XAGE3 →	+0.163	+4.906	<.001	.006	3	1
BLOOD_Myeloma	SCYGR2 →	+0.140	+4.807	<.001	.006	3	1
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	1
SKIN	CLRN2 →	+0.025	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

OR2H1 by EEA1 expression — OVARY

Explore this box plot interactively →