EDRF1

Across TCGA patient cohorts, EDRF1 mutation is significantly associated with the RNA expression of many other genes, with 4,593 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDRF1-associated genes across cancer lineages are NOP10, DRG1, and SAE1. Each is linked with EDRF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both EDRF1-to-partner and partner-to-EDRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOP10 grouped by EDRF1-low versus EDRF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDRF1→partner) and Y-score (partner→EDRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NOP10 →	+0.405	+4.365	<.001	<.001	3	4
UCEC	DRG1 →	+0.264	+2.616	.002	<.001	3	4
UCEC	SAE1 →	+0.457	+1.632	<.001	<.001	3	4
UCEC	TXN2 →	+0.335	+2.376	<.001	<.001	3	4
UCEC	SDHB →	+0.319	+2.280	.001	<.001	3	4
UCEC	ATP6V1E1 →	+0.338	+2.413	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,593 associations by consensus.

NOP10 by EDRF1 expression — UCEC

Explore this box plot interactively →