EDN2

Across TCGA patient cohorts, EDN2 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDN2-associated genes across cancer lineages are p70-S6K, AMPK_pT172, and TFRC. Each is linked with EDN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EDN2-to-partner and partner-to-EDN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by EDN2-low versus EDN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDN2→partner) and Y-score (partner→EDN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K →	+0.257	+3.026	.021	.019	3	1
UCEC	AMPK_pT172 →	+0.583	+3.013	.014	.019	3	1
UCEC	TFRC →	+0.830	+3.000	.006	.037	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

p70-S6K by EDN2 expression — UCEC

Explore this box plot interactively →