EDN2

Across TCGA cell cohorts, EDN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,165 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible EDN2-associated GO terms across cancer lineages are Artery smooth muscle contraction, Vein smooth muscle contraction, and Phasic smooth muscle contraction. Each is linked with EDN2 in more than 8 cancer types. Because this analysis shows association rather than direction, both EDN2-to-partner and partner-to-EDN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Artery smooth muscle contraction grouped by EDN2-low versus EDN2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EDN2→partner) and Y-score (partner→EDN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Artery smooth muscle contraction →	+1.275	+2.849	<.001	<.001	3	9
KIDNEY	Vein smooth muscle contraction →	+1.196	+2.382	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	Phasic smooth muscle contraction →	+1.820	+2.148	<.001	.003	3	8
BREAST	Tonic smooth muscle contraction →	+1.085	+1.669	.001	.005	3	8
OVARY	Platelet aggregation →	+0.129	+2.279	<.001	.004	3	7
LIVER	Regulation of ATP biosynthetic process →	+0.139	+2.434	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,165 associations by consensus.

Artery smooth muscle contraction by EDN2 expression — KIDNEY

Explore this box plot interactively →