EDF1

Across TCGA cell cohorts, EDF1 mutation is significantly associated with the mutation status of many other genes, with 1,861 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EDF1-associated genes across cancer lineages are SPECC1L, GGT1, and PRODH. Each is linked with EDF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EDF1-to-partner and partner-to-EDF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPECC1L grouped by EDF1-low versus EDF1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDF1→partner) and Y-score (partner→EDF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPECC1L →	+5.479	+6.145	<.001	<.001	1	1
BLOOD_Leukemia	GGT1 →	+4.309	+4.560	.007	.007	1	1
BLOOD_Leukemia	PRODH →	+4.309	+4.560	.007	.007	1	1
BLOOD_Leukemia	CYTH4 →	+4.894	+4.894	.004	.004	1	1
BLOOD_Leukemia	HIRA →	+4.157	+5.430	<.001	<.001	1	1
BLOOD_Leukemia	SEZ6L →	+3.479	+4.932	.002	.002	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,861 associations by consensus.

SPECC1L by EDF1 expression — BLOOD_Leukemia

Explore this box plot interactively →