EDEM2

Across TCGA patient cohorts, EDEM2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDEM2-associated genes across cancer lineages are ASNS, Cyclin-E2, and Src. Each is linked with EDEM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EDEM2-to-partner and partner-to-EDEM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by EDEM2-low versus EDEM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDEM2→partner) and Y-score (partner→EDEM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.516	+2.321	.003	.034	3	2
UCEC	Cyclin-E2 →	+0.174	+2.179	.033	.034	3	2
SKCM	Src →	-0.309	-3.000	.009	.035	3	1
UCEC	FoxM1 →	+0.306	+3.584	.014	.002	3	1
UCEC	MEK1 →	+0.393	+3.584	.026	.002	2	2
UCEC	Annexin_VII →	-0.178	-3.584	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ASNS by EDEM2 expression — UCEC

Explore this box plot interactively →